marc Lecouvey

Professeur

USPN, UFR SMBH, CB3S, ChemPhosBio
74, Rue Marcel Cachin
93017 BOBIGNY Cedex

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  +33 01 48 38 77 09

 

Biography

Marc Lecouvey obtained his PhD in Organic Chemistry from the University of Nancy 1 (France) in 1995. After two years as a post-doctoral researcher at the research laboratory of the company Ingredia (Arras, France), he became associate professor (1997) and professor (2004) at the Sorbonne Paris Nord University-USPN, where he heads the ChemPhosBio team (5 professors and associate professors). In 2016, he proposed the creation of the GDR CNRS around phosphorus chemistry and is currently in charge of its management (46 researchers, 32 laboratories). Since 2024, he is the director of the CB3S laboratory.  Since 2010, he has participated in 5 ANR projects. He has obtained several industrial research contracts and was a founding member of a start-up company, Phost'In therapeutics. He has supervised 15 PhD students and 8 postdoc researchers. Furthermore, he is co-author of 117 publications (h-index: 28; 2083 citations without self-citations), 2 books and  2 patents.

Research Topics

  • Phosphorus chemistry for biological applications.
  • Phosphorus chemistry for organocatalysis.

Most significant Publications

1- A Mild and Efficient One-pot Synthesis of 1-Hydroxymethylene-1,1-bisphosphonic Acids. Preparation of New Tripod Ligands. M. Lecouvey, I. Mallard, T. Bailly, R. Burgada, Y. Leroux Tetrahedron Lett. 2001, 42, 8475-8478.

2- Bis-Phosphonates–Ultra Small Superparamagnetic Iron Oxide Nanoparticles: A Platform Towards Diagnosis And Therapy. Y. Lalatonne, C. Paris, J.-M. Serfaty, P. Weinmann, M. Lecouvey, L. Motte Chem. Comm. 2008, 22, 2553-2555.

3- New Symmetrically Esterified M-Bromobenzyl Non Aminobisphosphonates Inhibited Breast Cancer Growth And Metastases. M. Abdelkarim, E. Guenin, O. Sainte-Catherine, N. Vintonenko, N. Peyri, G. Perret, M. Crepin, A.M. Khatib, M. Lecouvey, M. Di-Benedetto PLoSONE 2009, 4, e4685.

4- Synthesis And Biological Evaluation Of New Bisphosphonate-Dextran Conjugates Targeting Breast Primary Tumor. E. Migianu-Griffoni, I. Chebbi, S. Kachbi, M. Monteil, O. Sainte-Catherine, F. Chaubet, O. Oudar, M. Lecouvey Bioconjug. Chem. 2014, 25, 224-230.

5- Novel Easily Recyclable Bifunctional Phosphonic Acid- Carrying Tripeptides for the Stereoselective Michael Addition of Aldehydes with Nitroalkenes. M. Cortes-Clerget, O. Gager, M. Monteil, J-L. Pirat, E. Migianu-Griffoni, J. Deschamp, M. Lecouvey Adv. Synth. Catal. 2016, 358, 34-40.

Teaching

  • organic chemistry in PASS (1st year in medical school)
  • organic chemistry in Bachelor's degree
  • phosphonylated Prodrogues in master's degree pharmacology UPC