Maître de conférences
UFR SMBH, CB3S, ChemPhosBio, Bureau 332, 1 Rue de Chablis F-93000 Bobigny France
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+33 (0)1 48 38 77 26
Biography
Julia DESCHAMP graduated from Université Pierre et Marie Curie (UPMC, Paris). Then, Julia DESCHAMP started her doctoral studies under the supervision of Professor Olivier RIANT at Université catholique de Louvain (Belgium). In 2008, she received her PhD, for her works on domino reductive-aldol reaction catalyzed by a chiral copper (I) complex. After three year - Post-doctoral fellowships in different universities, she obtained an academic position as assistant professor in 2011 at Université Paris 13 (UMR CNRS 7244). Her area of expertise is organic synthesis and catalysis. Her research interests focus on synthetic methodology, including the design and synthesis of novel chiral organocatalysts. Dr. Julia Deschamp is co-author of 24 publications in international journals, 2 proceedings et de 1 patent (H-factor: 12 ; 546 without self-citations)
Research topics
Methodological develpment for the synthesis of organophosphorus derivatives. Application for the synthesis of biological relevant organophosphorus compounds and in asymmetric catalysis
Latest significant Publications
Synthesis of Aminobisphosphinates through a Cascade Reaction between Hypophosphorous Acid and Bis(trimethylsilyl)imidates Mediated by ZnI2. Ayadi, N.; Descamps, A.; Legigan, T.; Dussart-Gautheret, J.; Monteil, M.; Migianu-Griffoni, E.; Ben Ayed, T.; Deschamp, J.; Lecouvey, M. . Molecules 2023, 28. 10.3390/molecules28176226 This article belongs to the Special Issue "Recent Progress in Organophosphorus Chemistry"
One-Pot Synthesis of Phosphinylphosphonate Derivatives and Their Anti-Tumor Evaluations. J. Dussart-Gautheret, J. Deschamp, T. Legigan, M. Monteil, E. Migianu-Griffoni, M. Lecouvey, Molecules 2021, 26, 7609. DOI: 10.3390/molecules26247609. This article belongs to the Special Issue Featured Papers in Medicinal Chemistry
Formation of 1-Hydroxymethylene-1,1-Bisphosphinates through the Addition of a Silylated Phosphonite on various Trivalent Derivatives. J. Dussart, J. Deschamp, M. Monteil, O. Gager, T. Legigan, E. Migianu-Griffoni, M. Lecouvey J. Org. Chem. 2020 85, 14559-14569. DOI: 10.1021/acs.joc.0c01182. this article is part of a special issue "the new golden age of organophosphorus chemistry"
From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules. J. Dussart, J. Deschamp, E. Migianu-Griffoni, M. Lecouvey. Org. Process Res. Dev. 2020, 24, 637-651. DOI : 10.1021/acs.oprd.9b00490 this article is part of a special issue "a Taste of Current French Organic Chemistry"
A General Protocol for the Synthesis of H-α-Hydroxyphosphinates. J. Dussart, J. Deschamp, M. Monteil, O. Gager, E. Migianu-griffoni, M. Lecouvey . Synthesis, 2019, 51, 421-432. DOI: 10.1055/s-0037-1610274.
A convenient synthetic route towards H-bisphosphinates. J. Dussart, N. Guedeney, J. Deschamp, M. Monteil, O. Gager, T. Legigan, E. Migianu-Griffoni, M. Lecouvey. Org. Biomol. Chem., 2018, 16, 6969-6979. DOI : 10.1039/C8OB01878B.
Bifunctional Tripeptide with a Phosphonic Acid as a Bronsted Acid for Michael Addition: Mechanistic Insights: Cortes-Clerget, M.; Jover, J.; Dussart, J.; Kolodziej, E.; Monteil, M.; Migianu-Griffoni, E.; Gager, O.; Deschamp, J.; Lecouvey, M., Chem. Eur. J. 2017, 23, 6654-6662. DOI : 10.1002/chem.201700604
Novel Easily Recyclable Bifunctional Phosphonic Acid Carrying Tripeptides For The Stereoselective Michael Addition Of Aldehyde With Nitroakenes: Cortes-Clerget, M. ; Gager, O. ; Monteil, M. ; Migianu-Griffoni, E. ; Pirat, J.L. ; Deschamp, J. ; Lecouvey, M. Adv. Synth. Catal. 2016, 358, 34-40. DOI : 10.1002/adsc.201500794
Patent
Nouveau complexe métallique chiral et son utilisation pour des réactions d’hydroamination énantiosélectives
Schulz, E.; Collin, J.; Hannedouche, J.; Eyglunent, C.; Deschamp, J. WO2011101563A1.
Teaching
PACES (1st year od medical school), bachelor in Science of Life (L1, L2, L3)
All publications
Synthesis and preliminary anticancer evaluation of photo-responsive prodrugs of hydroxymethylene bisphosphonate alendronate. Descamps, A.; Arnoux, P.; Frochot, C.; Barbault, F.; Deschamp, J.; Monteil, M.; Migianu-Griffoni, E.; Legigan, T.; Lecouvey, M. Eur. J. Med. Chem. 2024, 269, 116307. https://doi.org/10.1039/D3NJ04980A
Characterization, Antioxidant and Anticholinesterase Activity of Compounds Isolated from Alkaloid Extracts of Citrus aurantifolia Root Bark. Zıale, D. A. E.; Adou, D. A.; gaman-kouassı, K. C. C.; Deschamp, J.; Bouchemal, N.; Palama, T. L.; Lecouvey, M.; Mamyrbekova-békro, J. A.; Bekro, Y.-A. JOTCSA 2024, 11, 1227. https://doi.org/10.18596/jotcsa.1395690
Synthesis of new alendronate analogs for bone-targeted drug delivery strategies. Guedeney, N.; Deschamp, J.; Legigan, T.; Monteil, M.; Migianu-Griffoni, E.; Lecouvey, M. New J. Chem. 2024, 48, 1436. Doi : https://doi.org/10.1039/D3NJ04980A.
Towards the Synthesis of New Sequestring Hexadentate Bisphosphonic Ligands for Iron Ion Chelation. Ouechtati, M.; Kouame, C.; Deschamp, J.; Legigan, T.; Touil, S.; Migianu-Griffoni, E.; Monteil, M.; Lecouvey, M. Phosphorus Sulfur Silicon Relat. Elem. 2023, 199, 210. Doi : https://doi.org/10.1080/10426507.2024.2316787
Synthesis of Aminobisphosphinates through a Cascade Reaction between Hypophosphorous Acid and Bis(trimethylsilyl)imidates Mediated by ZnI2. Ayadi, N.; Descamps, A.; Legigan, T.; Dussart-Gautheret, J.; Monteil, M.; Migianu-Griffoni, E.; Ben Ayed, T.; Deschamp, J.; Lecouvey, M. . Molecules 2023, 28. 10.3390/molecules28176226 Impact factor : 4.6 This article belongs to the Special Issue "Recent Progress in Organophosphorus Chemistry"
Structural characterization and in vitro biological exploration of phytoconstituents isolated from a chloroform extract of Rauvolfia vomitoria (Apocynaceae) root bark from Côte d’Ivoire - Ziale, D. A. E.; Ngaman Kouassi, K. C. C.; Deschamp, J.; Bouchemal, N.; Palama, T. L.; Lecouvey, M.; Mamyrbekova Bekro, J. A.; Bekro, Y. A., J. Pharmacogn. Phytochem. 2023, 12, 06-14. doi: 10.22271/phyto.2023.v12.i1a.14541 (IF : 5.52)
One-Pot Synthesis of Phosphinylphosphonate Derivatives and Their Anti-Tumor Evaluations. J. Dussart-Gautheret, J. Deschamp, T. Legigan, M. Monteil, E. Migianu-Griffoni, M. Lecouvey, Molecules 2021, 26, 7609. DOI: 10.3390/molecules26247609. Impact factor : 4.412 This article belongs to the Special Issue Featured Papers in Medicinal Chemistry
Synthesis and Preliminary Anticancer Evaluation of New Triazole Bisphosphonate-based Isoprenoid Biosynthesis Inhibitors. T. Legigan, E. Migianu-Griffoni, M.A. Abdenour, A. Descamps, J. Deschamp, O. Gager, M. Monteil, F. Barbault, M. Lecouvey, Eur. J. Med. Chem. 2021, 214,133241. DOI : 10.1016/j.ejmech.2021.113241. Impact factor : 5.572
Formation of 1-Hydroxymethylene-1,1-Bisphosphinates through the Addition of a Silylated Phosphonite on various Trivalent Derivatives. J. Dussart-Gautheret, J. Deschamp, M. Monteil, O. Gager, T. Legigan, E. Migianu-Griffoni, M. Lecouvey J. Org. Chem. 2020 85, 14559-14569 DOI: 10.1021/acs.joc.0c01182. Impact factor : 4.745 this article is part of a special issue "the new golden age of organophosphorus chemistry"
From Industrial Method to the Use of Silylated P(III) Reagents for the Synthesis of Relevant Phosphonylated Molecules. J. Dussart, J. Deschamp, E. Migianu-Griffoni, M. Lecouvey. Org. Process Res. Dev. 2020, 24,637-651.DOI : 10.1021/acs.oprd.9b00490 this article is part of a special issue "a Taste of Current French Organic Chemistry" Impact factor : 3.327
A General Protocol for the Synthesis of H-α-Hydroxyphosphinates. J. Dussart, J. Deschamp, M. Monteil, O. Gager, E. Migianu-griffoni, M. Lecouvey . Synthesis, 2019, 51, 421-432. DOI: 10.1055/s-0037-1610274. Impact factor : 2.867
A convenient one-pot synthesis of 1-hydroxymethylene-1,1-bisphosphinic acids. N. Guedeney, J. Dussart, J. Deschamp, M. Ouestati, E. Migianu-Griffoni, M. Lecouvey. Phosphorus Sulfur Silicon Relat. Elem. 2019, 194, 323-325. DOI: 10.1080/10426507.2018.1540001. Impact factor : 0,674
A convenient synthetic route towards H-bisphosphinates. J. Dussart, N. Guedeney, J. Deschamp, M. Monteil, O. Gager, T. Legigan, E. Migianu-Griffoni, M. Lecouvey. Org. Biomol. Chem., 2018, 16, 6969-6979. DOI : 10.1039/C8OB01878B. Impact factor : 3,490
Bifunctional Tripeptide with a Phosphonic Acid as a Bronsted Acid for Michael Addition: Mechanistic Insights: Cortes-Clerget, M.; Jover, J.; Dussart, J.; Kolodziej, E.; Monteil, M.; Migianu-Griffoni, E.; Gager, O.; Deschamp, J.; Lecouvey, M., Chem. Eur. J. 2017, 23, 6654-6662. DOI : 10.1002/chem.201700604 Impact factor : 5,160
Novel Easily Recyclable Bifunctional Phosphonic Acid Carrying Tripeptides For The Stereoselective Michael Addition Of Aldehyde With Nitroakenes: Cortes-Clerget, M. ; Gager, O. ; Monteil, M. ; Migianu-Griffoni, E. ; Pirat, J.L. ; Deschamp, J. ; Lecouvey, M. Adv. Synth. Catal. 2016, 358, 34-40. DOI : 10.1002/adsc.201500794 Impact factor : 5,646
Towards potential nanoparticle contrast agents: Synthesis of new functionalized PEG bisphosphonates: Kachbi-Khelfallah, S.; Monteil, M.; Cortes-Clerget, M.; Migianu-Griffoni, E.; Pirat, J. L.; Gager, O.; Deschamp, J.; Lecouvey, M., Beilstein J. Org. Chem. 2016, 12, 1366-1371 Impact factor : 2.337
M. CORTES-CLERGET, O. GAGER, M. MONTEIL, E. MIGIANU-GRIFFONI, J. DESCHAMP, M. LECOUVEY, Phosphorus Sulfur Silicon Relat. Elem. 2016, 191, 1593-1594. . IF 2015: 0.723
Synthesis of novel polymerizable molecules bearing bisphosphonate: Kachbi-Khelfallah, S ; Monteil, M ; Deschamp, J ; Gager, O ; Migianu-Griffoni, E ; Lecouvey, M. Org. Biomol. Chem. 2015, 13, 11382-11392. Impact factor : 3.559
An easy route toward enantio-enriched polycyclic derivatives via an asymmetric domino conjugate reduction-aldol cyclization catalyzed by a chiral Cu(I) complex. Deschamp, J.; Hermant, T.; Riant, O. Tetrahedron 2012, 68, 3457-3467. Impact factor : 2.803
Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes. Deschamp, J.; Mondon, M.; Nakagaw, S.; Kato, A.; Alonzi, D.S.; Butters, T.D.; Zhang, Y.; Sollogoub, M.; Blériot, Y. Bioorg. Med. Chem. 2012, 20, 641-649. Impact factor : 2.903
Cavitand supported tetraphosphine: cyclodextrin offers a useful platform for Suzuki-Miyaura cross-coupling. Zaborova, E.; Deschamp, J.; Guieu, S.; Blériot, Y. ; Poli, G. ; Ménand, M. ; Madec, D. ; Prestat, G. ; Sollogoub, M. Chem. Comm. 2011, 47, 9206-9208. Impact factor : 6.169
Easy routes towards chiral lithium binaphthylamido catalysts for the asymmetric hydroamination of amino-1,3-dienes and aminoalkenes. Deschamp, J.; Collin, J. ; Hannedouche, J. ; Schulz, E. Eur. J. Org. Chem. 2011, 3329-3338. Impact factor : 3.329
Simple chiral diaminobinaphtyl silithium satls for intramolecular catalytic asymmetric hydroamination of amino-1,3-dienes. Deschamp, J.; Olier, C.; Schulz, E.; Guillot, R.; Hannedouche, J.; Collin, J. Adv. Synth. Catal. 2010, 352, 2171-2176. Impact factor : 5.25
An Efficient Construction of Polycyclic Derivatives via a High Selective CuI-Catalyzed Domino Reductive-Aldol Cyclization. Deschamp, J.; Riant, O. Org. Lett. 2009, 11, 1217-1220. Impact factor : 5.42
Copper (I) Catalyzed Enantio- and Diastereoselective Tandem Reductive Aldol Reaction.Chuzel, O.; Deschamp, J.; Chausteur, C.; Riant, O. Org. Lett. 2006, 8, 5943-5946. Impact factor : 4.659
Highly Diastereo- and Enantioselective Copper-Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate. Deschamp, J.; Chuzel, O.; Hannedouche, J.; Riant, O. Angew. Chem. Int. Ed. 2006, 45, 1292-1297 (VIP). Impact factor : 10.232
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